If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. You may also experience withdrawal symptoms.
Methadone should be given with caution and the initial dose reduced in certain patients, such as the elderly and debilitated and those with severe impairment of hepatic or renal function, hypothyroidism, Addison's disease, prostatic hypertrophy, or urethral stricture.
Teratogenic Effects. Pregnancy Category C – There are no controlled studies of methadone use in pregnant women that can be used to establish safety. However, an expert Bericht of published data on experiences with methadone use during pregnancy by the Teratogen Information Anlage (TERIS) concluded that maternal use of methadone during pregnancy as parte of a supervised, therapeutic regimen is unlikely to pose a substantial teratogenic risk (quantity and quality of data assessed as “limited to fair”). However, the data are insufficient to state that there is no risk (TERIS, belastung reviewed October, 2002). Pregnant women involved in methadone maintenance programs have been reported to have significantly improved prenatal care leading to significantly reduced incidence of obstetric and fetal complications and neonatal morbidity and mortality when compared to women using illicit drugs.
Geriatric – The pharmacokinetics of methadone have not been evaluated hinein the geriatric Individuenbestand.
Particular vigilance is necessary during treatment initiation, during conversion from one opioid to another, and during dose titration.
gemischt, um euphorisierende Wirkungen zu vermeiden → verhindert die Gefahr des schädlichen Opioidkonsums, sobald es injiziert statt oral eingenommen wird
If you have a paralytic ileus (lack of muscle tone in the intestines that can cause Us-soldat obstructions), you shouldn’t take this drug.
Intravenously administered naloxone or nalmefene may be used to reverse signs of intoxication. Because of the relatively short half-life of naloxone as compared with methadone, repeated injections may Beryllium required until the Verfassung of the patient remains satisfactory. Naloxone may also Beryllium administered by continuous intravenous infusion.
Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and Sachverständigengutachten of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication.
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Your kidneys may not work as well as they used to. This can cause Methadontabletten online kaufen your body to process drugs more slowly. As a result, a higher amount of a drug stays hinein your body for a longer time. This raises your risk of side effects.
Deaths have been reported during conversion to methadone from chronic, high-dose treatment with other opioid agonists and during initiation of methadone treatment of addiction in subjects previously abusing high doses of other agonists.
Dosage adjustment using higher doses or administering the daily dose in divided doses may Beryllium necessary in pregnant women treated with methadone (see CLINICAL PHARMACOLOGY and DOSAGE AND ADMINISTRATION).
For people with liver problems: If you have liver problems or a history of liver disease, you may not be able to process this drug well. This may increase the levels of methadone hinein your body and cause more side effects. Your doctor should watch you closely if you take this drug.